Clinical Resources

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Disclaimer: This website and its content is intended as a resource for clinicians caring for critically-ill COVID-19 patients, based on available evidence and recommendations of governing bodies. The recommendations do not replace clinical judgment or the need for individualized patient care plans. While we attempt to keep this website up-to-date, the literature on COVID-19 is rapidly evolving, and we suggest that practitioners search for the most up-to-date literature on any specific topic. These guidelines will also rapidly evolve as they are implemented into clinical practice and we receive feedback from practitioners. Additionally, local factors should be taken into account if utilized.
 

Updates Included:

 
Patient Impact of COVID-19 in U.S.
Active Cases Deaths Recovered
6,829,847 201,403 4,120,133
*totals as of September 17, 2020
Clinical Articles and Studies

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

  • This is a prospective meta-analysis of 7 randomized trials for the treatment of critically ill patients with COVID-19 that included 1,703 patients – 647 of whom died.
  • The 28-day all-cause mortality was lower among patients who received corticosteroids compared to those who received usual care or placebo.

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Considering the Potential for an Increase in Chronic Pain After the COVID-19 Pandemic

  • Chronic pain is impacted by and affects all aspects of the bio-psycho-social model with significant individual, family and societal consequences.
  • As we gain a better understanding of COVID's longer-term effects on these three fronts, we will also need to address the health issues directly or indirectly related to COVID's sequela.

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COVID-19 and the Path to Immunity

  • Understanding the features and evolution of B-cell and T-cell mediated adaptive immunity to COVID-19 is essential for developing effective control strategies. 
  • This article includes a review of acute and long-term adaptive response and addresses reinfection as well as the two critical paths to vaccine modulation: Neutralizing antibodies and boosting antiviral CD8+ and TH1 CD4+ T cells.

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6 Months Later – What We've Learned

  • While new information about the virus is published daily, here are five things we know right now that we didn’t know in March.
  • COVID-19 is not the flu; surges occur in pockets; necessity is the mother of innovation; health and wellness are critical; misinformation is a serious concern.

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